Recently, cytotoxic T cells were found to be markedly increased in areas of the brain with tau pathology in transgenic mice with tauopathy and in individuals with AD, and T cell infiltration was shown to drive tau-mediated neurodegeneration [26], and CD8+ T cells induced plaque and tangle-like deposition, modulated AD-related genes and promoted neurodegeneration [27]. This evidence concerns the gene CD8A and Alzheimer disease.