Enhanced CD8+ T‐cell responses have also been demonstrated following therapeutic vaccination and checkpoint blockade in the SIV model of infection, where ART‐suppressed SIV‐infected rhesus macaques were vaccinated with a DNA/modified vaccinia Ankara vaccine regimen and given an anti‐PD‐1 antibody at the time of vaccination (both prime and boost). This evidence concerns the gene CD8A and infection.