The survival analysis indicated that certain genes, including PCNA clamp-associated factor (PCLAF), ribonucleoside-diphosphate reductase subunit M2 (RRM2), nucleolar and spindle-associated protein 1 (NUSAP1), and kinesin family member 23 (KIF23), could be instrumental in the development, invasion, or recurrence of glioblastoma. The gene discussed is RRM2; the disease is glioblastoma.