Of these, all 204 patients (100%) had NT-proBNP levels > 300 ng/L, 187 (91%) had reduced LVGLS (<18% numerical) with apical sparing pattern, 155 (76%) had heart failure symptoms requiring treatment with loop diuretics, (37%) had prior carpal tunnel syndrome surgery, and 50 (24%) had a diagnosis of aortic stenosis of varying type and severity. The gene discussed is NPPB; the disease is heart failure.