There is a wide variety of drugs for the treatment of diabetes, among which insulin therapy is the most effective method, and other antidiabetic drugs including biguanides, sulfonylureas, α-glycosidase inhibitors, non-sulfonylureas insulin secretogens, thiazolidinediones and other hypoglycemic drugs are also widely used in clinical practice (10). The gene discussed is INS; the disease is diabetes mellitus.