SAP18, as an integral splicing component of the exon junction complex (EJC)-related apoptosis and splicing associated protein (ASAP)/PNN-RNPS1-SAP18 (PSAP) complex40, is associated with seven AS events including IRF4_SE, DPEP2_A3 etc. Previous studies reported that SAP18 is involved in the apoptosis signaling pathway in T-cell acute lymphoblastic leukemia (T-ALL)41 and non-Hodgkin lymphoma42, affecting disease progression. Here, PNN is linked to T-cell acute lymphoblastic leukemia.