Although our research has shown that METTL16 modifies SYNPO2L at the mRNA level through m6A, enabling SYNPO2L to function more effectively, and SYNPO2L promotes the secretion of COL10A1 and the infiltration of tumor-associated fibroblasts, thereby facilitating EMT in tumor cells and making them more prone to distant metastasis. The gene discussed is SYNPO2L; the disease is neoplasm.