SQSTM1 and neoplasm: The molecular studies performed have indicated that SRL is able to potentiate PDT through by increasing PpIX and ROS production, responsible for cell stress and, at the same time, avoiding an efficient antioxidant response by impairing the axis p62/NRF2/HO-1/NQO1 in charge of managing created ROS, provoking an increase in tumor cell death.