TIMER2.0 database (http://timer.comp-genomics.org/) displayed that SLC16A1 was positively correlated with M2 markers (CD206 and CD163), but not with macrophage general markers (CD68) and M1 macrophage markers (CD80, CD86, iNOS) in HCC tissues (Supplementary Fig. S3A). The gene discussed is SLC16A1; the disease is hepatocellular carcinoma.