Herein, we found a higher ING5 expression in HCC than normal tissues in both mRNA and protein levels, and a positive correlation of ING5 expression with multiple malignant clinicopathological parameters including a higher serum AFP level, vascular invasion, and histological grade of tumor, as well as poor OS, PFS, RFS, and DSS of HCC patients. The gene discussed is AFP; the disease is neoplasm.