Moreover, while PD-L1 expression was dose-dependently inhibited by SAS or AS101 in B16/F10 cells (Fig. 4B), AML cells (Fig. 4G) or A549 cells (Fig. S3B) transfected with a control plasmid, this inhibition was abrogated when Akt was overexpressed (Fig. 4C, F and Fig. S3C) (see transfections in Fig. S1A, C and F). The gene discussed is CD274; the disease is acute myeloid leukemia.