PDIA5 and glioblastoma: Furthermore, we also compared the expression of the CCAR1 protein between GBM cells with overexpression of wild-type PDIA5 and mutated PDIA5 motifs of CXXC, and the results showed that the CCAR1 protein was up-regulated in LV-PDIA5 rather than GBM cells LV-mPDIA5 (Figure 4I).