Wound healing assays showed that the cell migration ability was significantly weakened with PDIA5 knock-down (Figure 3D-E); Transwell invasion assays also indicated that the invasion ability of the GBM cells declined after PDIA5 inhibition (Figure F-G). Furthermore, the CCK-8 and EdU assays demonstrated that the proliferation ability of tumor cells was reduced after PDIA5 removal (Figure 3I-L). This evidence concerns the gene PDIA5 and glioblastoma.