Next, we found the expression of TNF-α, IFN-γ and CD107a representative of cytotoxicity in CD8+ T cells were all elevated (Figure 2K-P) in the the ABCC4-KO group, implying that genetic ablation of ABCC4 in tumor cells could restore the anti-tumor effects of CD8+ T cells. This evidence concerns the gene CD8A and neoplasm.