TNFRSF1B and cancer: Therefore, the potent antitumor effect of TNFR2-targeting nanoparticles is likely attributable to the preferential accumulation of ADR contained in TNFR2-PLGA-ADR in the tumor microenvironment and the target of TNFR2-expressing Tregs and cancer cells, while we could not exclude the EPR (enhanced permeability and retention) effect of nanodrugs.