showed that HCC cell‐derived exosomes can act on macrophages to reduce the secretion of IL‐6, IL‐1β, IL‐10, and TNF‐α, thereby activating the signal transduction and activator of transcription 3 (STAT3) pathway and upregulating PD‐L1 expression. The gene discussed is STAT3; the disease is hepatocellular carcinoma.