EPHA2 and pachyonychia congenita: found that showed that the combination of exosome‐EphA2 + CA19‐9 + CA242 can not only improve the ability to diagnose PC at an early stage, but also improve the ability to differentiate PC from benign pancreatic diseases, using exosome‐EphA2 + CA19‐9 + carbohydrate antigen 242 (CA242) as an early diagnostic marker.