They further revealed that exosomal lncRNA‐SOX2OT derived from NSCLC cells targeted the miRNA‐194‐5p/RAC1 signaling axis, the TGF‐/pTHrP/RANKL signaling pathway in osteoblasts to regulate osteoclast development and trigger NSCLC BoM.171. The gene discussed is RAC1; the disease is non-small cell lung carcinoma.