By immunohistochemical analysis of cancer tissues from 291 invasive breast cancer patients, Jeong YJ et al. investigated the correlation between LOXL3 expression and clinicopathological parameters, and they reported significant relationships of LOXL3 expression with ER expression, PR expression, and breast cancer molecular subtypes (P<0.001) 50. The gene discussed is LOXL3; the disease is breast cancer.