We screened patients for immunohistochemical experiments using the same criteria as HE, and the patient information is shown in Table S2, Similarly, our immunohistochemical results also indicated that the tissue expression levels of MMP-2, MMP-3, MMP-7, MMP-12, MMP-13, and MMP-19 were higher than those of the control (p < 0.0001, respectively) (Figure 6A-D). The gene discussed is MMP12; the disease is hereditary elliptocytosis.