To elucidate the mechanism of MMP regulation in diverse cell types in CC, we identified DEGs in individuals between MMPs high-expression and low-expression groups, finally it was found MMP-1, MMP-12, MMP-13 and MMP-7 were upregulated, but MMP-14, MMP-19, MMP-2, and MMP-21 were downregulated in diverse cell types (Figure 1D), suggesting biochemically redundant members of the MMP family may have intricate interplay in tumor progression. This evidence concerns the gene MMP21 and neoplasm.