As for chemokines, the CXCL9/10/11-CXCR3 axis has been proven to promote the recruitment of immune cells into the tumor, remodeling the tumor immune microenvironment 64,65, the up-regulation of CXCL9/10/11 implies necroptosis may exert an anti-tumor effect by enhancing the infiltration of immune cells in the TME. This evidence concerns the gene CXCR3 and neoplasm.