Additionally, interventions targeting Twist in peritoneal metastatic cancer have been studied by Huang et al., who demonstrated that dextran sulfate (DS) inhibits hypoxia-inducible factor-1α (HIF-1α) expression, suppresses TGF-β-mediated EMT in gastric cancer cells, and thus inhibits gastric cancer peritoneal metastasis 42. Here, TWIST1 is linked to gastric cancer.