In order to identify the key regulators in the ICD risk subgroups, first we verified the mRNA expression levels of these eight genes, and we found that only SFTPB and SERPIND1 were highly expressed in normal tissues, whereas FAM83A, FDCSP, KRT6A, RHOV and TPX2 were highly expressed in tumor tissues (Figure 10A). This evidence concerns the gene RHOV and neoplasm.