For instance, the nonsynonymous SNPs C677T (rs1801133) and A1298C (rs1801131) in the MTHFR gene reduce the enzyme activity of the gene-encoded protein, 5,10-methylenetetrahydrofolate reductase, consequently affecting non-Hodgkin lymphoma susceptibility 46. Here, MTHFR is linked to non-Hodgkin lymphoma.