Moreover, the association between abnormal expression of CDH3 and cancer prognosis has been reported in many cancers, such as pancreatic cancer 9, thyroid cancer 10, tongue squamous cell carcinoma 11-13, liver cancer 14, gastric cancer 15, esophageal cancer 16,17, cholangiocarcinoma 18, renal cell carcinoma 19, breast cancer 20-22, prostate cancer 23, lung cancer 24 and glioblastoma 25. The gene discussed is CDH3; the disease is cancer.