Consistently, several studies have revealed that genetic polymorphisms in one-carbon-metabolizing pathway genes and folate-metabolizing genes, such as thymidylate synthase, serine hydroxymethyltransferase, methionine synthase, and MTHFR, can modify NHL predisposition 9, 12, 24, 25, 30, 31, 41. Here, MTHFR is linked to non-Hodgkin lymphoma.