Furthermore, Jian Ren et al. found that overexpression of tRFdb-3003a/b may play a key role in tumor progression of gliomas, tRFdb-3003a/b may inhibit tumor proliferation and growth by directly binding to VAV2 to regulate VAV2 expression in gliomas (Figure 3F) 74. The gene discussed is VAV2; the disease is central nervous system cancer.