Wang et al. showed that the expression of tiRNA-1:33-Pro-TGG-1 (5′tiRNA-Pro-TGG) was higher in SSLs than that in healthy population, while 5′tiRNA-Pro-TGG and heparanase 2 (HPSE2) were found a significant negative correlation between their expression levels, another analysis of survival outcomes in CRC patients demonstrated that the lower level of HPSE2 was associated with poorer prognosis (Figure 4A) 64. This evidence concerns the gene HPSE2 and colorectal carcinoma.