The expression levels of tRF-Arg-CCT-017 in HER-2 subtypes, and expression levels of tRF-Gly-CCC-001 and tiRNA-Phe-GAA-003 differ between luminal BC and TNBC, reflecting obvious heterogeneity, suggesting that tRF-Arg-CCT-017, tRF-Gly-CCC-001 and tiRNA-Phe-GAA-003 can serve as novel diagnostic biomarkers for BC (Figure 2E) 49. The gene discussed is ERBB2; the disease is breast cancer.