By contrast, SUSD2 expression was significantly downregulated in colon adenocarcinoma, kidney chromophobe, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, and rectum adenocarcinoma, indicating a dual role of SUSD2 across different types of cancer. This evidence concerns the gene SUSD2 and chromophobe renal cell carcinoma.