By contrast, SUSD2 expression was significantly downregulated in colon adenocarcinoma, kidney chromophobe, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, and rectum adenocarcinoma, indicating a dual role of SUSD2 across different types of cancer. Here, SUSD2 is linked to rectum adenocarcinoma.