In conclusion, we found that AR extract can reduce the expression of METTL3, reduce the RNA m6A modification of UCK2, accelerate the degradation of UCK2, reduce the expression of UCK2, and thereby downregulate the Wnt signalling pathway, which is one of the key mechanisms involved in weakening the invasion and migration of melanoma cells and inhibiting the growth of tumours. The gene discussed is AR; the disease is melanoma.