In addition paper, using transcriptomics, we constructed a cytotoxicity-related prognostic prediction risk model consisting of six key genes (SOWAHB, SLC16A12, IL20RB, SLC12A8, PLG, and HHLA2), precise and concise, showing a preferable application prospect that benefits the prognostic evaluation personalized treatment for ccRCC patients. The gene discussed is HHLA2; the disease is nonpapillary renal cell carcinoma.