Therefore, analysis for LGMD would have been the next diagnostic step in the genetic work-up if we had not decided with the rheumatologists to test for 3-hydroxy-3-methylglutaryl coenzyme A reductase ((HMGCR) IgG antibodies because the CK levels above 1,500 U/L, the biopsy findings and the response to steroids which are more suggestive of a non-genetic diagnosis [1]. The gene discussed is HMGCR; the disease is limb-girdle muscular dystrophy.