For example, ICI-induced pneumonitis, inflammatory arthritis, and colitis are predominantly driven by both CD4+ and CD8+ T cells and T-cell derived proinflammatory cytokines such as IFN-γ, TNF-α, IL-6, and IL-17 (105, 109, 111, 161, 162, 169). The gene discussed is TNF; the disease is pneumonitis.