CTLA4 and melanoma: Melanoma (B16-OVA) burdened CD11c-Cre+Stat3f/f (Stat3Δ/Δ) mice, which are prone to autoinflammatory colitis, experienced a decrease in body weight and enhanced histological evidence of colitis following anti-CTLA-4 administration when compared to isotype control and Stat3+/+ groups (117).