In conjunction with an abundance of effector T cell responses, myeloid cells in ICI-colitis also display an inflammatory gene signature enriched in TNF-α- and IFNγ-inducible elements such as CXCL16, CXCL9 and CXCL10, which encode chemokines that attract CXCR6+ and CXCR3+ T cells, respectively (109). The gene discussed is TNF; the disease is colitis.