IL1B and pneumonitis: Additionally, low levels of IL-1β, IL-8, and macrophage inflammatory protein-3a (MIP-3a), and an increase in IL-12p40, IFN-γ-induced protein 10 (IP-10 or CXCL-10), CCL17, and T cell chemoattractant protein TARC were observed in the cell-free BAL supernatant of ICI-pneumonitis patients, compared to the non-ICI-treated group, suggesting that these immune dysregulations in ICI-pneumonitis patients may be potential predictive markers and therapeutic targets (162).