The histology of the tumor tissue samples revealed that the group of mice consuming high Zn (T+Zn) showed elevated levels of pus zones (H&E staining) (Figure 1E), a higher level of Ki67 expression (immunohistochemistry, IHC) (Figure 1F), and a higher level of melanin production (Masson’s Fontana staining) (Figure 1G) compared to the control group consuming a normal diet (T). The gene discussed is MKI67; the disease is neoplasm.