We also found Rg3 inhibited the glycosylation of PD-L1 in H1299 cells, which also exhibit high level of glycosylated PD-L1 (Supplementary Figure S1A).To address how Rg3 affected PD-L1 glycosylation, we noticed that previous researches identified EGFR-GSK3β signaling controls the glycosylation in breast cancer cells (13). Here, EGFR is linked to breast cancer.