ACAT1 and neoplasm: Supplementary Figure S1A shows a network of ACAT1 and its 10 coexpression genes. The correlation analyses between the expression of ACAT1 and co-expressed genes in gastric cancer from TCGA are shown in Supplementary Figures S1B–I. As shown in Supplementary Figure S1J, changes in the biological process of ACAT1 are associated with increased intramolecular oxidoreductase activity, suggesting that ACAT1 may suppress tumor initiation and progression by inhibiting the production of ROS.