It has been reported to target several key factors in HF, such as the anti-hypertrophic transcriptional factor Forkhead Box O3 (FoxO3) (19), the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERC2a) in heart contractility (20) and the Ras GTPase-activating protein 1 (RASA1) of angiogenesis (21). Here, FOXO3 is linked to hydrops fetalis.