The etiology of TAO remains uncertain, yet it is commonly associated with the breakdown of immune tolerance toward the thyrotropin receptor (TSHR) and irregular levels of thyrotropin receptor antibodies (TRAbs) (McLachlan and Rapoport, 2014; Diana et al., 2021; Nicolì et al., 2021). The gene discussed is TSHR; the disease is thromboangiitis obliterans.