Barish et al. suggest that BICRA variants, presenting similarly to those seen in SSRIDD patients, such as moderate developmental delay, autism, intellectual disability, behavioral issues, and dysmorphic facial features, may represent a subgroup of the SWI/SNF complex, differing from Coffin-Siris syndrome by the lack of the fifth-digit/nail hypoplasia [11]. This evidence concerns the gene SMARCA1 and Coffin-Siris syndrome.