Bandhyopadhyay et al. also observed a significant difference in COX-2 expression patterns between in-situ cervical intraepithelial neoplasia (CIN) and invasive squamous cell carcinoma (SCC), with higher expression in the invasive cases (p=0.0002) [4]. Here, PTGS2 is linked to cervical intraepithelial neoplasia.