On the other hand, the neuroendocrine theory emphasizes dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis [15], leading to increased release of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol, ultimately resulting in damage to hippocampal cells and cortical neuronal atrophy. This evidence concerns the gene POMC and Atrophy.