Research on ROCO proteins significantly intensified since the identification of links between ROCO proteins and human disease, notably, leucine-rich repeat kinase 2 (LRRK2) with Parkinson’s disease (PD) and death-associated protein kinase 1 (DAPK1) with cancer (Marín, 2006; Terheyden, 2018). This evidence concerns the gene DAPK1 and Parkinson disease.