In the future, genetic testing using tissue samples from stereo-EEG electrodes may identify somatic variants during epilepsy presurgical evaluation, as previously reported in other epileptogenic malformations.14, -, 16 This could pave the way for exploring personalized treatment strategies targeting the Shh signaling pathway, already in use in cancers,17 to HH cases with persisting seizures after initial surgery. The gene discussed is SHH; the disease is epilepsy.