SHH and cancer: In the future, genetic testing using tissue samples from stereo-EEG electrodes may identify somatic variants during epilepsy presurgical evaluation, as previously reported in other epileptogenic malformations.14, -, 16 This could pave the way for exploring personalized treatment strategies targeting the Shh signaling pathway, already in use in cancers,17 to HH cases with persisting seizures after initial surgery.