Table 1 lists the most statistically significant variant for each of the 15 genes. Among them, rs367543041, also known as c.1144G>A (p.A382T), is a missense variant of TARDBP (TAR DNA binding protein), which has been identified to be associated with ALS risk in multiple previous studies.31, -, 33 This SNP was not available among imputed variants in the validation data set from dbGaP. Instead, we tested 2 nearby variants upstream and downstream, rs3835416 and rs148414479, as proxies. The association p-values for the 2 variants were 0.008 and 0.202, respectively. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.