This result aligns with previous studies reporting rs367543041 as an ALS risk variant.31, -, 33 The TARDBP variation, particularly the p.A382T missense variant (rs367543041), has been linked to approximately 30% of ALS cases within the genetically conserved Sardinian population.32,33 Although we could not directly replicate this variant in the larger dbGaP data set because this SNP was not included in the imputed genotype, we observed an association with a nearby proxy SNP, supporting the involvement of TARDBP variation in ALS susceptibility. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.