ZNF235 encodes a zinc finger protein that acts as a transcriptional repressor, potentially participating in neuronal differentiation.50,51 Both GWAS and TWAS analyses suggest associations between ZNF235 and ALS, with predicted ZNF235 expression levels in the caudate and skeletal muscle tissues showing reduced expression levels among ALS cases. This evidence concerns the gene ZNF146 and amyotrophic lateral sclerosis.