Of keen interest in this work, was the significant magnetic particle concentration difference between MMC Brodmann 4 and medulla versus ALS cases with higher SIRM, along the loss of nuclear TDP-43 expression (i.e., nuclear clearing) in cortical and subcortical motor and sensory neurons in young MMC urbanites (Calderón-Garcidueñas et al., 2024b; Calderón-Garcidueñas et al., 2020; Calderón-Garcidueñas et al., 2022d). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.