Gingerol has been reported to increase the expression of APC, p53, and TUNEL-positive nuclei and, subsequently, decrease the expression of TNF-α, IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and cyclin D1 in male BALB/c mice with colorectal cancer (Farombi et al., 2020). Here, TP53 is linked to colorectal cancer.