The 27 biomarkers with significant differences included: Gender, Age, History of Stroke, Carotid atherosclerosis, Hypertension, Diabetes, Homocysteine, White Blood Cell Count, Monocyte count, Basophil Count, Urea, Uric Acid, Creatinine, Carbon Dioxide Content in Plasma, Fibrinogen, Globulin, Albumin to Globulin Ratio, Free Thyroxine, Total Cholesterol, High-Density Lipoprotein, Low-Density Lipoprotein, Lipoprotein (a), Apolipoprotein A1, Apolipoprotein E, Monocyte-to-HDL Ratio, Neutrophil-to-HDL Ratio, Lymphocyte-to-Monocyte Ratio (Table 1). The gene discussed is APOE; the disease is carotid atherosclerosis.