BCHE and Cognitive impairment: Given that evidence suggeststhat the selective inhibition of BChE may have a beneficial effectin dementia disorders4 and that depressionand musculoskeletal pain as well as stress incontinence are relativelycommon in the elderly suffering from cognitive impairments, the treatmentof these patients with duloxetine may be more beneficial than thetreatment with other antidepressant drugs.