Inother words, subjects with the K variant of BChE show resistance againstdeveloping cognitive impairment through their 30% intrinsic BChE inhibition.6 Animal study on BChE inhibitors supports thenotion that the selective inhibition of BChE may improve both thecognitive function as well as modulate the brain levels of β-amyloidpeptides.7 The gene discussed is BCHE; the disease is Cognitive impairment.