In conclusion, duloxetine was foundto be a potent BChE inhibitorwith a highly probable in vivo effect, given thatBChE can coregulate the cholinergic signaling by acting on acetylcholine,4 particularly in elderly populations or in cognitivelyimpaired older adults in whom BChE levels may have been elevated.4 Duloxetine as a novel BChE inhibitor should betherefore considered the choice of treatment in older adults withboth depressive and dementia symptoms. Here, BCHE is linked to dementia.