MAPK14 and acute myeloid leukemia: In particular,the underlying molecular mechanisms of Mtx-C include apoptotic andnecroptotic activation, the induction of stress signaling pathwaysinvolving mitogen-activated protein kinases (MAPKs) p38 and c-Jun,and DNA damage.9,10 Herein, we explored the effectof Mtx-C on the proliferation and myeloid differentiation of AML cellsand primitive subsets of LSCs using concentrations below the half-maximaleffective concentration (EC50) with a proliferation assayand determined that Mtx-C has low cytotoxicity.