TP53 and malignant colon neoplasm: Pubescens, and S. quelpaertensis) against MCF-7 breast cancercells and HCT-116 colon cancer cells lines has been reported, showingcytotoxic, antiproliferative, proapoptotic, and proin-flammatory effects.7,67 A recent study investigated the role of NO• andinhibitors of apoptosis (IAPs) during the process of apoptosis inducedby S. quelpaertensis leaf extracts (SQE) in p53 wild-type(WT) and p53 null HCT-116 colon carcinoma cells.