For example, a blockage ofthe hERG potassium ion channels by the evaluated drugs could resultin the induction of lethal cardiac arrhythmias.41 Furthermore, in the case of the hepatic cytochrome P450enzymes, these are a polymorphic multigene enzyme family that playa role in the metabolism of drugs, steroids, and other compounds.42 This evidence concerns the gene KCNH2 and chronic obstructive pulmonary disease.