However, ectopic expression of NAT10 in MeWo and A375 cells (Figures 2F, G) remarkably augmented the resistance to DTIC treatment (Figure 2H) and abrogated DTIC-induced melanoma apoptosis, as evidenced by the increased IC50 value and decreased apoptosis rate (Figures 2I, J). The gene discussed is NAT10; the disease is melanoma.