Preoperative inflammatory responses may be elevated in colorectal cancer (CRC) patients experiencing anastomotic leakage, as indicated by increased levels of serum C-X-C Motif Chemokine Ligand 6 and C-C Motif Chemokine Ligand 11 in individuals with rectal cancer and heightened levels of serum high-sensitivity CRP in those with colon cancer (39). Here, CRP is linked to rectal cancer.