Thiazolidinediones exhibit anticancer effects by disrupting the cell cycle, cell proliferation, cell differentiation, and apoptosis in cancer cells.[64] They are implicated in inhibiting the function of Bcl‐2/Bcl‐xL, which activates caspases, ultimately inducing apoptosis.[65] Additionally, TZDs contribute to the proteasomal degradation of specific proteins and transcriptional repression of AR through Sp1 degradation, thereby inhibiting gene expression and impeding cell growth, which prevents cancer progression (Figure 3).[66]. This evidence concerns the gene SP1 and cancer.